Epigenetic “Drivers” of Cancer

Genetics is at the basis of cancer initiation and evolution, but emerging evidence indicates that mutations are not sufficient to produce cancer, indicating a role for epigenetic contributions different stages tumorigenesis. While genetic tracks have been widely investigated, “drivers” remain vague definition. Gene-environment interactions can gene-regulatory programs dictate pathogenesis; this implies reciprocal relationship where environmental factors contribute mechanisms tumorigenesis (i.e. mutagenesis) influence cellular response extrinsic stress. In review article, we attempt summarise most remarkable findings demonstrating contribution as proper We also try pose attention on relevance downstream consequences genes versus environment interaction.